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Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

By Ian Dettman - Posted on 10 March 2011

This article is a great review of the author's understanding of the role of adjunctive treatments at end of life.

Ichim TE, Minev B, Braciak T, Luna B, Hunninghake R, Mikirova NA, Jackson JA, Gonzalez MJ, Miranda Massari JR, Alexandrescu DT, Dasanu C, Bogin V, Ancans J, Stevens RB, Markosian B, Koropatnick J, Chen CS, Riordan NH. Intravenous ascorbic acid to prevent and treat cancer-associated sepsis? J Transl Med. 2011 Mar 4;9(1):25. [Epub ahead of print] PubMed PMID: 21375761

Get the full paper here

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Ian Dettman's blog

Access to Parenteral Thiamine

Biological Therapies supplies a range of registered injections containing parenteral thiamine.
See the TGA website: http://www.tga.gov.au/safety/alerts-medicine-ivthiamine-100728.htm
See also the SHPA website: SHPA Manufacturers Alerts (Thiamine Injection)

Pub Med Highlights

Assessing the survival of mrc-5 and a549 cell lines upon exposure to ascorbic Acid and sodium ascorbate - biomed 2011

Delayed treatment with vitamin C and N-acetyl-L cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib

Effect of oral suplementation of vitamin C on intestinal anastomotic resistance

Protective effects of vitamin C against haematological and biochemical toxicity induced by deltamethrin in male Wistar rats

Vitamin C status is related to proinflammatory responses and impaired vascular endothelial function in healthy, college-aged lean and obese men

Does prophylactic therapy with antioxidant vitamins have an effect on atrial fibrillation following cardiac surgery?

Dietary Intakes of Antioxidant Vitamins and Mortality From Cardiovascular Disease - The JACC Study

Transmission of hepatitis C virus to recipients of parenteral vitamin therapy in a primary care facility.

Ascorbate decreases the mucosal immune inflammatory response to gliadin in coeliac disease patient

Vitamin C increases the apoptosis via up-regulation p53 during cisplatin treatment in human colon cancer cells

Intravenous ascorbic acid (vitamin C) administration in myomectomy, a prospective, randomized, clinical trial

Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C

Emerging role of thiamine therapy for prevention and treatment of early stage diabetic nephropathy

Revisiting the ALA-N (alpha-lipoic acid - low-dose naltrexone) protocol for people with pancreatic cancer

Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in type 2 diabetes patients

Meet the team

From Ian's Desk

Inaugural Meeting of World Federation of Chinese Medicine Societies - WFCMS - China May 2011 - Conference and Invitation

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

Attending Japanese College of Intravenous Therapy 2010 - a great success

Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: RCT

Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer

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