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Ascorbate decreases the mucosal immune inflammatory response to gliadin in coeliac disease patient
Bernardo D, Martínez-Abad B, Vallejo-Diez S, Montalvillo E, Benito V, Anta
B, Fernández-Salazar L, Blanco-Quirós A, Garrote JA, Arranz E.
Ascorbate-dependent decrease of the mucosal immune inflammatory response to
gliadin in coeliac disease patients. Allergol Immunopathol (Madr). 2011 Mar
17. [Epub ahead of print] PubMed PMID: 21420224
Gliadin-challenge induced IL-15 production in biopsies from treated CD
patients, while the addition of ascorbat e to culture medium completely
inhibited IL-15 production. Moreover, the inhibition of IL-15 by ascorbate
took place even in the only treated CD-patient who had basal IL-15
production. Ascorbate decreases the mucosal inflammatory response to gluten
in an intestinal biopsy culture model, so it might have a role in future
supplementary therapy in CD.
Access to Parenteral Thiamine
Biological Therapies supplies a range of registered injections containing parenteral thiamine.
See the TGA website: http://www.tga.gov.au/safety/alerts-medicine-ivthiamine-100728.htm
See also the SHPA website: SHPA Manufacturers Alerts (Thiamine Injection)
